As far as the entourage effect is concerned, THC and CBD are the most well-studied chemicals in the marijuana plant. They have been shown to operate differently when combined than when used separately.
The combination of CBD and THC has been found to reduce adverse effects and increase effectiveness, with CBD + THC being more beneficial for some illnesses than THC alone.
Chemical Structure
Chemically speaking, CBD and THC have the same chemical formula: 21 carbons, 30 hydrogen atoms, and two oxygen atoms each. Atoms are organized differently, which is the distinction between the two. Because of this, CBD and THC have distinct chemical characteristics, and they have different effects on your body.
Cannabis Cultivars with A High CBD Content Can Help with Pain Management
When combined with THC, CBD is more effective in treating pain than THC alone. If you’re using CBD on its own, it’s most effective for inflammatory pain, such as arthritis or trauma.
When CBD Cream was applied topically to arthritis-affected animals, it reduced inflammation and discomfort. Through the reduction of chronic inflammation, another animal study revealed that CBD reduces neuropathic pain by inhibiting chronic inflammation.
CBD is considered to reduce inflammation, mostly through inhibiting inflammatory mediators, to reduce pain. Glycine receptors, which help control pain at the spinal level, are also considered to be potentiated by it. neuropathic and inflammatory pain are both suppressed as a result of this.
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Treatment Of Pain with High-THC Strains
In therapeutic settings, THC is utilized to alleviate central and neuropathic pain, according to research. It is also used to assist decrease pain in cancer, AIDS, and fibromyalgia patients, for whom conventional pain medications have proven ineffective due to resistance.
Evidence From Anecdotal Sources
THC, CBD, and whole-plant marijuana have been shown to relieve pain in human trials, although much of the evidence for this usage comes from user reports and surveys. Thirty-five percent of Canadians with chronic, non-cancer pain reported using cannabis for pain treatment in a poll.
CBD Or THC As an Analgesic?
Consider the amount of THC and CBD in a strain while looking for the finest cannabis strains for pain treatment. As a general rule, a strain with a high CBD: THC ratio will provide the greatest relief for you. THC’s side effects are mediated by CBD, which also has anti-inflammatory and analgesic qualities.
There are instances when the effects of a greater THC or higher CBD strain may be preferable. If you have inflammation but don’t want the psychoactive effects of THC, one example is if you want to go about your day normally. In this case, a high-CBD, low-THC strain can give comfort without affecting mental function too significantly.
Other times, you may be in enough agony to want anything to distract you from it while simultaneously providing pain relief. In this case, the stronger “high” that a high-THC strain would provide may be beneficial.
Pain-Relieving Cannabis Strains
Aside from the fundamental percentages of CBD and THC, there are a few factors to think about. One of these factors to consider is the sort of cannabis you’re buying. Your medicinal marijuana can fall into one of three categories:
- Indica
- Sativa
- Hybridized (a mixture of both Indica and Sativa)
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While it is not a precise science, indicas have been reported to have more effective pain-relieving qualities by consumers. Indicas were shown to be more effective than sativas in treating headaches, joint pain, neuropathy, and spasticity in one study. Indicas were also considered to be more beneficial for sleep and sedation by users.
Finally, there are several user reports on certain strains of marijuana that are effective for pain relief. While some of these strains are CBD-rich indicas, certain pain-relieving marijuana strains do not fit into this group.
The other cannabinoids, terpenes, and flavonoids may have found a harmonic balance, resulting in potent pain-relieving effects.